Research Artilces

Preprints and Conference Proceedings:
  We appreciate comments and suggestions on our manuscripts posted in a preprint server, which helps us to do a better job.
  1. Xiaolong Wang, Haibo Peng, Chunyan Li, Xuxiang Wang, Yalei Wang, Gang Chen, Jianye Zhang, Premature termination codons signaled targeted gene repair by nonsense mRNA-mediated gene editing in E. coli, BioRxiv, April 24, 2017, doi:
  2. Xiaolong Wang, Quanjiang Dong, Gang Chen, Jianye Zhang,Yongqiang Liu, Jinqiao Zhao, Haibo Peng, Yalei Wang, Yujia Cai,Xuxiang Wang, Chao Yang,  Why are frameshift homologs widespread within and across species?, BioRxiv, April 17, 2017, doi:
  3. Xiaolong Wang, Polymerase-endonuclease amplification reaction (PEAR) for the production of modified oligonucleotides, The 42nd International Symposium on Nucleic Acids Chemistry (ISNAC 2015),  1OP-04, P46-47, September 23-29, 2015, Hyogo, Japan.
  4. Wang Xiaolong, Wang Xuxiang, Chen Gang, Zhang Jianye, Liu Yongqiang, Yang Chao. (2015The shiftability of protein coding genes: the genetic code was optimized for frameshift tolerating. PeerJ PrePrints 3e806v1
  5. Wang Xiaolong, Yang Chao. (2015) CAUSA 2.0: accurate and consistent evolutionary analysis of proteins using codon and amino acid unified sequence alignments. PeerJ PrePrints 3:e1486
  6. Wang Xiaolong, Fu Yu , Zhao Yue , Wang Qi , Pedamallu Chandra Sekhar , Xu,Shuang-yong , Niu Yingbo , and Hu Jingjie. (2011) Accurate Reconstruction of Molecular Phylogenies for Proteins Using Codon and Amino Acid Unified Sequence Alignments (CAUSA). Available from Nature Precedings <>

Journal Articles:

  1. Wang Xuxiang, Zhang Jianye, Li Yingjia, Chen Gang, Wang Xiaolong*. Enzymatic Synthesis of Modified Oligonucleotides by PEAR Using Phusion and KOD DNA Polymerases. Nucleic Acid Therapeutics. February 2015, 25(1): 27-34. PubMed PMID: 25517220. doi:10.1089/nat.2014.0513
  2. Biao Li, Shihua Dong, Jiajun Wu, Jianye Zhang, Gang Chen, Quanjiang Dong, Xinhong Zhu, Xiaolong Wang* (2013) Preparation of 5′-O-(1-Thiotriphosphate)-Modified Oligonucleotides Using Polymerase-Endonuclease Amplification Reaction (PEAR). PLoS ONE 8(7): e67558. doi:10.1371/journal.pone.0067558
  3. Shuang-yong Xu, Rebecca L. Nugent, Julie Kasamkattil, Alexey Fomenkov, Yogesh Gupta, Aneel Aggarwal, Xiaolong Wang, Zhiru Li, Yu Zheng, and Richard Morgan (2012) Characterization of Type II and III restriction-modification systems from Bacillus cereus strains ATCC10987 and ATCC14579, Journal of Bacteriology, 194(1): 49-60, doi:10.1128/JB.06248-11
  4. Xiaolong WANG, Deming GOU, Shuang-yong XU. (2010) Polymerase- Endonuclease Amplification Reaction (PEAR) for Large-Scale Enzymatic Production of Antisense Oligonucleotides. PLoS ONE, 5(1): e8430. doi:10.1371/journal.pone.0008430.
  5. Xiaolong WANG, Zhenmin BAO, Jingjie HU, Deming GOU. (2008) DNA computing solves the 3-SAT problem with a small solution space, Current Nanoscience, 4 (4): 354-360. DOI: 10.2174/157341308786306099
  6. Xiaolong WANG, Zhenmin BAO, Jingjie HU, Shi WANG, Aibin ZHAN, (2008), Solving the SAT problem using a DNA computing algorithm based on ligase chain reaction, Biosystems, 91: 117–125. doi:10.1016/j.biosystems.2007.08.006
  7. Xiaolong WANG, Jingjie HU, Jie PAN, Zhuojun MA, Ke BI, Quanqi ZHANG  and Zhenmin BAO. (2004), Polyethylenimine promotes sperm-mediated transgene and oligonucleotide delivery in abalone haliotis discus hannai. Journal of shellfish Research, 23(4): 1123-1127
  8. Shi WANG, Lingling ZHANG , Aibin ZHAN, Xiaolong WANG, Zhanjiang Liu, Jingjie Hu and Zhenmin BAO. (2007), Patterns of concerted evolution of an rDNA family in a natural population of Zhikong scallop, Chlamys farreri. J. Molecular Evolution. 65(6): 660-667
  9. Aibin ZHAN, Jingjie HU, Xiaolong WANG, Wei Lu, Min Hui and Zhenmin Bao. (2006) A panel of polymorphic EST-derived microsatellite loci for the bay scallop (Argopecten irradians) J. Molluscan Studies, 72: 435-438
  10. AIBIN ZHAN, ZHENMIN BAO, BING YAO, XIAOLONG WANG, MIN HUI, JINGJIE HU. (2006) Polymorphic microsatellite markers in the Zhikong scallop, Chlamys farreri, Molecular Ecology Notes, 6: 127-129
  11. [Xiaolong WANG, Jie PAN,Shi WANG, et al. (2006) Identification of the Raw Material of Ejiao Using the CytB Gene PCR-RFLP Method, PERIODICAL OF OCEAN UNIVERSITY OF CHINA, 36 (4): 645-648   (Article in Chinese)  ]
  12. [Xiaolong WANG, Zhifa YUAN, et al. (2002) Maximum entropy principle and population genetic equilibrium, ACTA GENETICA SINICA, 29(6) 562-564 (Article in Chinese) [PDF]


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